Pini Alessandro

Anno accademico 2017/18

[MG005] - MEDICAL BIOTECHNOLOGIES

• 2001497 - ANTIBODIES AND PEPTIDES FOR DRUG DELIVERY

ME001 - BIOTECNOLOGIE

• 2001076 - BIOCHIMICA METABOLICA E LABORATORIO
• 2001105 - ANTICORPI RICOMBINANTI

ME011 - TECNICHE DI LABORATORIO BIOMEDICO

• 2012296 - CHIMICA BIOLOGICA

ME013 - TECNICHE DI FISIOPATOLOGIA CARDIOCIRCOLATORIA E PERFUSIONE CARDIOVASCOLARE

• 108676/1 - BIOCHIMICA

ME014 - IGIENE DENTALE

• 108692/2 - CHIMICA E BIOCHIMICA

Scuola di Specializzazione in OFTALMOLOGIA

• BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA

Scuola di Specializzazione in MALATTIE INFETTIVE

• BIOLOGIA MOLECOLARE

E’ autore di decine di articoli scientifici pubblicati su giornali di biochimica, biotecnologia, oncologia e microbiologia, di più di 90 comunicazioni a congressi nazionali ed internazionali, ed inventore in 9 brevetti internazionali. E’ autore di un libro di testo adottato per l’insegnamento di Anticorpi Ricombinanti nel Corso di Biotecnologie all’Università di Siena.

Principali pubblicazioni ultimi 5 anni:

• Pini A, Lozzi L, Bernini A, Brunetti J, Falciani C, Scali S, Bindi S, Di Maggio T, Rossolini GM, Niccolai N, Bracci L.
  “Efficacy and toxicity of the antimicrobial peptide M33 produced with different counterions.”
  Amino Acids (2012) 43, 467-473
• Falciani C, Lozzi L, Pollini S, Luca V, Carnicelli V, Brunetti J, Lelli B, Bindi S, Scali S, Di Giulio A, Rossolini GM, Mangoni ML, Bracci L and Pini A.
  “Isomerization of an antimicrobial peptide broadens antimicrobial spectrum to Gram-positive bacterial pathogens”
  PLoS One (2012), 7, e46259
• Luca V, Stringaro A, Colone M, Pini A and Mangoni ML.
  “Esculentin(1-21), an amphibian skin membrane-active peptide with potent activity on both planktonic and biofilm cells of the bacterial pathogen Pseudomonas aeruginosa”
  Cellular and Molecular Life Science (2013), 70, 2773-2786
• Falciani C, Brunetti J, Lelli B, Ravenni N, Lozzi L, Depau L, Scali S, Bernini A, Pini A, Bracci L.
  “Cancer selectivity of tetra-branched neurotensin peptides is generated by simultaneous binding to sulfated glycosaminoglycans and protein receptors”.
  Journal of Medicinal Chemistry (2013), 56, 5009-5018
• Roscia G, Falciani C, Bracci L, Pini A.
  “The Development of Antimicrobial Peptides as New Antibacterial Drugs”
  Current Protein and Peptide Sciences (2013), 14, 641 - 649
• Falciani C, Lozzi L, Scali S, Brunetti J, Bracci L, Pini A.
  “Site-specific pegylation of an antimicrobial peptide increases resistance to Pseudomonas aeruginosa elastase”
  Amino Acids (2014), 46, 1403-1407
• Brunetti J, Lelli B, Scali S, Falciani C, Bracci L, Pini A.
  “A Novel Phage-Library-Selected Peptide Inhibits Human TNF-α Binding to Its Receptors”
  Molecules (2014), 19, 7255-7268
• Brunetti J, Falciani C, Lelli B, Minervini A, Ravenni N, Depau L, Siena G, Tenori E, Menichetti S, Pini A, Carini M and Bracci L.
  “Neurotensin branched peptide as a tumor-targeting agent for human bladder cancer"
  BioMed Research International (2015), 2015:173507
• Di Grazia A, Cappiello F, Cohen H, Casciaro B, Luca V, Pini A, Di YP, Shai Y, Mangoni ML.
  “D-Amino acids incorporation in the frog skin-derived peptide esculentin-1a(1-21)NH2 is beneficial for its multiple functions”
  Amino Acids (2015), 47, 2505-2519
• Brunetti J, Pillozzi S, Falciani C, Depau L, Tenori E, Scali S, Lozzi L, Pini A, Arcangeli A, Menichetti S, Bracci L.
  “Tumor-selective peptide-carrier delivery of Paclitaxel increases in vivo activity of the drug”
  Scientific Reports (2015), 5, 17736
• Ceccherini F, Falciani C, Onori M, Scali S, Pollini S, Rossolini GM, Bracci L, Pini A.
  “Antimicrobial activity of levofloxacin-M33 peptide conjugation or combination”
  MedChemComm (2016), 7, 258 - 262
• Brunetti J, Falciani C, Roscia G, Pollini S, Bindi S, Scali S, Arrieta UC, Gómez-Vallejo V, Quercini L, Ibba E, Prato M, Rossolini GM, Llop J, Bracci L, Pini A.
  “In vitro and in vivo efficacy, toxicity, bio-distribution and resistance selection of a novel antibacterial drug candidate”
  Scientific Reports (2016), 6, 26077
• Brunetti J, Depau L, Falciani C, Gentile M, Mandarini E, Riolo G, Lupetti P, Pini A, Bracci L.
  “Insights into the role of sulfated glycans in cancer cell adhesion and migration through use of branched peptide probe”
  Scientific Reports (2016), 6, 27174
• Brunetti J, Roscia G, Lampronti I, Gambari R, Quercini L, Falciani C, Bracci L, Pini A.
  “Immunomodulatory and Anti-inflammatory Activity in Vitro and in Vivo of a Novel Antimicrobial Candidate”
  The Journal of Biological Chemistry (2016), 291, 25742-25748
• “Esculentin-1a-Derived Peptides Promote Clearance of Pseudomonas aeruginosa Internalized in Bronchial Cells of Cystic Fibrosis Patients and Lung Cell Migration: Biochemical Properties and a Plausible Mode of Action”
  Antimicrobial Agents Chemotherapy (2016), 60, 7252-7262
• Brunetti J, Falciani C, Bracci L, Pini A.
  “Models of In-Vivo Bacterial Infections for the Development of Antimicrobial Peptide-based Drugs”
  Current Topics Medicinal Chemistry (2017) 17, 613-619
• Pollini S, Brunetti J, Sennati S, Rossolini GM, Bracci L, Pini A, Falciani C.
  “Synergistic activity profile of an antimicrobial peptide against multidrug-resistant and extensively drug-resistant strains of Gram-negative bacterial pathogens”
  Journal of Petide Sciences (2017), 23, 329-333
• van der Weide H, Brunetti J, Pini A, Bracci L, Ambrosini C, Lupetti P, Paccagnini E, Gentile M, Bernini A, Niccolai N, Jongh DV, Bakker-Woudenberg IAJM, Goessens WHF, Hays JP, Falciani C.
  “Investigations into the killing activity of an antimicrobial peptide active against extensively antibiotic-resistant K. pneumoniae and P. aeruginosa”
  Biochim Biophys Acta (2017), 1859, 1796-1804
• Depau L, Brunetti J, Falciani C, Scali S, Riolo G, Mandarini E, Pini A, Bracci L.
  “Coupling to a cancer-selective heparan-sulfate-targeted branched peptide can by-pass breast cancer cell resistance to methotrexate”
  Oncotarget (2017), in press